Question: Can exosome-based interventions reverse the inflammatory progression of COPD? Answer: COPD involves chronic airway inflammation and emphysema often triggered by cigarette smoke or environmental pollutants. Therapeutic exosomes, particularly those derived from immunomodulatory cells, have shown the ability to suppress the infiltration of neutrophils and macrophages in the lungs. Implementing exosome-based therapies for COPD focuses on restoring the protease-antiprotease balance and promoting the regeneration of airway epithelial cells, offering a promising alternative to conventional bronchodilators and steroids.