Optimizing Therapeutic Antibodies: Strategies for ADCC and CDC...

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2026-06-16 02:05:57 -

Optimizing Therapeutic Antibodies: Strategies for ADCC and CDC Enhancement

Key Takeaways: Monoclonal antibodies (mAbs) rely heavily on Fc-mediated effector functions, primarily ADCC and CDC, for their clinical efficacy in oncology and infectious diseases. Modifying the Fc region through specific point mutations or glycosylation profiles significantly alters binding affinity to Fcγ receptors and complement proteins. Advanced engineering approaches now allow for...

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