Copper-Free Click Chemistry and Bioorthogonal Reactions: The New...

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2026-06-16 02:53:41 -

Copper-Free Click Chemistry and Bioorthogonal Reactions: The New Engine for Next-Generation ADCs

Antibody-Drug Conjugates (ADCs) have unequivocally transformed the landscape of targeted oncology. By marrying the precision of monoclonal antibodies with the lethal potency of cytotoxic payloads, ADCs offer a "magic bullet" approach to cancer therapy. However, despite their clinical success, traditional bioconjugation methods—such as stochastic modification of lysine or cysteine...

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