Beyond the Transcriptome: Unveiling Cellular Secrets Through Ribosome Footprinting and Multi-Omics Integration
For decades, the central dogma of molecular biology has guided our understanding of life: DNA makes RNA, and RNA makes protein. However, recent breakthroughs in high-throughput sequencing have revealed a startling reality—mRNA levels often fail to correlate with protein abundance. This discrepancy suggests that the true "control room" of the cell lies not in transcription, but in the...
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