Point-of-care testing technology has exceptional capabilities for detecting biomarkers for a wide range of diseases thanks to its speed, ease of use, efficiency and cost-effectiveness. One such POCT strategy is the lateral flow immunoassay. It is a well-established testing platform and a powerful tool for rapid, low-cost detection as it requires no specialized equipment, and results can be...
Organoids are 3D microstructures that are cultured in vitro and derived from human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) obtained from healthy individuals or patients. They are capable of reproducing the cellular heterogeneity, structure, and function of human organs. Human 3D organoid systems allow the extremely detailed observation of stem cell morphogenetic factors,...
AAVs are small, non-enveloped, single-stranded DNA viruses that were discovered in the 1960s as contaminants of adenovirus preparations. They induce limited host immune responses and are not associated with any known diseases. However, they have been found to efficiently deliver DNA cargo to many tissues in multiple animal species. Thus, AAV vectors are widely used as gene transfer tools in...
With the success of messenger RNA (mRNA) vaccines against SARS-CoV-2 and the approval of several RNA interference (RNAi) agents in recent years, the era of RNA medicine has become a reality. RNA therapeutics show great promise as the next generation of treatments for a wide array of diseases. Therefore, many efforts are underway to develop nano-vehicles that can deliver therapeutic RNA...
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